Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg - CAS Number: 2307477-23-0 Molecular

- CAS Number: 2307477-23-0 Molecular Formula: C18H22ClN3O5 Molecular Weight: 395

Indisulam promotes the recruitment of RBM39 (RNA binding motif protein 39) to the CUL4-DCAF15 E3 ubiquitin ligase

Product Name DOTA-C4-alcohol Synonyms CAS Number n/a Related CAS Molecular Formula C20H37N5O8 Molecular Weight 475

392 Purity (HPLC) >= 95% Solubility DMSO

473 SMILES O=C1N(CC2=C(NCCOCCOCCOCC#C)C=CC=C12)C1CCC(=O)NC1=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg - CAS Number: 2307477-23-0 MolecularSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by